Simona Pagliuca

This paper develops a scalable method to expand human CD4- iNKT cells from PBMCs using IL-15 and -GalCer, showing improved GVHD control and GVL activity in preclinical models.

This study examines how different transplantation platforms affect the clonal and transcriptional changes in αβ and γδT cells over time, finding that graft engineering has a lasting impact on βTCR clonality, while viral reactivation mainly drives expansion without altering repertoire structure.

The paper identifies immune endotypes in OA synovial tissue using integrated molecular and spatial profiling to guide precision medicine.

This study profiles genomic and immunogenomic features of eAML, finding clonal branching and immune editing, with FLT3 mutations in relapsed cases.