Mara J.T. Nicolasen

The paper shows that DCs use reverse MHC class I signaling to polarize their MTOC and Golgi toward T cells, enabling localized IL-12 release for T cell activation.

This study examines how different transplantation platforms affect the clonal and transcriptional changes in αβ and γδT cells over time, finding that graft engineering has a lasting impact on βTCR clonality, while viral reactivation mainly drives expansion without altering repertoire structure.

The paper develops a γδT-omics pipeline to analyze compartmentalization of Vδ1⁺ T cell migration, tumor-reactivity, and clonality in human colorectal cancer, revealing distinct functional and transcriptional features across tumor compartments.