This study examines how different transplantation platforms affect the clonal and transcriptional changes in αβ and γδT cells over time, finding that graft engineering has a lasting impact on βTCR clonality, while viral reactivation mainly drives expansion without altering repertoire structure.

bioRxiv · Feb 10, 2026 · PreprintImmunology

De novo H3.3K27M-altered Diffuse Midline Glioma in human brainstem organoids to dissect GD2 CAR T cell function

Nils Bessler, Amber K. L. Wezenaar, Hendrikus CR Ariese, Celina Honhoff, Noëlle Dommann, Ellen J. Wehrens, Cristian Ruiz-Moreno, Thijs J M van den Broek, Raphaël V U Collot, Daan J. Kloosterman, Farid Keramati, Mieke M Roosen, Sam de Blank, Esmée J. van Vliet, Mario Barrera Román, , Anne C. Rios

This paper develops a human brainstem organoid model of H3.3K27M-altered DMG to study GD2 CAR T cell function and identify therapeutic targets.

Nature Cancer · Jan 5, 2026Peer-reviewedCancer Biology

Functional γδT-omics pipeline reveals compartmentalization of Vδ1⁺ T cell migration, tumor-reactivity, and clonality in human colorectal cancer

Lucrezia C D E Gatti, Mara J.T. Nicolasen, Farid Keramati, Péter Brázda, Angelo D. Meringa, Dorine A. De Bont, Tineke Aarts‐Riemens, Willemijn J. C. Brandwijk, Maud I.M. van der Wijst, Anniek Stuut, Laia Gasull-Celades, Daniel Zawal, Konstantinos Vazaios, Annet Daudeij, Maarten A. Huismans, , Jurgen H. E. Kuball

The paper develops a γδT-omics pipeline to analyze compartmentalization of Vδ1⁺ T cell migration, tumor-reactivity, and clonality in human colorectal cancer, revealing distinct functional and transcriptional features across tumor compartments.

bioRxiv · Aug 19, 2025 · PreprintImmunology