Targeting AXL Overcomes Adaptive Resistance to KRAS Inhibition in KRAS-Driven Cancer
Fredrik I. Thege, Annaliese Kramer, Norbert Kreisz, Intisar Salim, Etsehiwot Girum Girma, Linara Welte, Elizabeth Adams, Ashton Pluchinsky, Elijah Kirschstein, Olivia E. Harder, Amber Hoskins, Ashwath Seetharaman, Kimal Rajapakshe, Yuki Makino, Andrew J. Gunderson, , Anirban Maitra
This study identifies AXL as a driver of adaptive resistance to KRAS inhibition and shows that combining AXL and KRAS inhibition improves tumor control and immune response in lung and pancreatic cancer models.
bioRxiv · Aug 4, 2026 · PreprintCancer Biology