Fredrik I. Thege

Targeting AXL Overcomes Adaptive Resistance to KRAS Inhibition in KRAS-Driven Cancer

This study identifies AXL as a driver of adaptive resistance to KRAS inhibition and shows that combining AXL and KRAS inhibition improves tumor control and immune response in lung and pancreatic cancer models.

Metabolic Reprogramming by Mutant GNAS Creates an Actionable Dependency in Intraductal Papillary Mucinous Neoplasms of the Pancreas

This study shows that mutant GNAS drives a gastric metaplasia gene signature and glycolytic dependency in IPMNs, offering a therapeutic target.

Adar1 deletion causes degeneration of exocrine pancreas via Mavs-dependent interferon signaling

This study shows that Adar1 deletion in mice causes exocrine pancreas degeneration through Mavs-dependent interferon signaling, which is rescued by concurrent Mavs deletion.