BAP1 deubiquitinase is a potent repressor of fetal hemoglobin biosynthesis
Lei Yu, Natee Jearawiriyapaisarn, Mary P. Lee, Tomonori Hosoya, Qingqing Wu, Greggory Myers, Kim-Chew Lim, Ryo Kurita, Yukio Nakamura, Anne B. Vojtek, Jean-Francois M. Rual, James Douglas Engel
The paper identifies BAP1 as a key repressor of fetal hemoglobin biosynthesis by maintaining NCoR1 at the β-globin locus and shows its inhibition increases γ-globin synthesis.
bioRxiv · Jun 13, 2018 · PreprintDevelopmental Biology