Lei Yu

This study identifies aspartate transaminases GOT1 and GOT2 as critical for erythropoiesis by linking metabolism to epigenetic regulation, revealing a novel role in blood development.

The paper identifies a lipid metabolism defect as a contributor to variable anemia in Diamond Blackfan anemia syndrome using a murine model and transcriptomic analysis.

The paper shows that deleting the 3HS1 CTCF binding site increases fetal hemoglobin expression in hematopoietic stem cells and erythroid progenitor cells, suggesting therapeutic potential for hemoglobinopathies.

This paper describes a novel Rpl5 mutation in mice that models Diamond Blackfan Anemia with variable penetrance and anemia remission.

This study shows that LSD1 promotes erythropoiesis by repressing myeloid fate, and inhibiting myeloid factors reverses lineage conversion caused by LSD1 inactivation in mice and human HSPC.

The paper identifies BAP1 as a key repressor of fetal hemoglobin biosynthesis by maintaining NCoR1 at the β-globin locus and shows its inhibition increases γ-globin synthesis.