Developmental BiologybioRxivPreprint
The epigenetic eraser LSD1 lies at the apex of a reversible erythroid to myeloid cell fate decision
Lei Yu, Greggory Myers, Chia-Jui Ku…·James Douglas Engel
This study shows that LSD1 promotes erythropoiesis by repressing myeloid fate, and inhibiting myeloid factors reverses lineage conversion caused by LSD1 inactivation in mice and human HSPC.