Arrestin-3 agonism at D3 dopamine receptors defines a subclass of second generation antipsychotics that promotes drug tolerance
Selin Schamiloglu, Elinor Lewis, Caroline M. Keeshen, Anne C. Hergarden, Kevin J. Bender, Jennifer Lynne Whistler
This study identifies some second generation antipsychotics (SGAs) as arrestin-3 agonists at D3 dopamine receptors, showing that chronic use leads to receptor degradation and altered drug efficacy.
Biological Psychiatry · Mar 15, 2023Peer-reviewedNeuroscience