Caroline M. Keeshen

CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder

This study shows that CRISPR activation can rescue electrophysiological deficits in SCN2A haploinsufficiency by increasing the expression of the remaining functional allele in mice and human neurons.

G protein-Coupled Receptor Associated Sorting ProteinGASP1 mediated trafficking of the Glucagon Like Peptide-1Receptor contributes to the development of tolerance toincretin drugs

This study shows that GASP1-mediated GLP-1R trafficking contributes to tolerance to incretin drugs, suggesting a strategy to prevent tolerance by biasing drug engagement toward G protein signaling.

Arrestin-3 agonism at D3 dopamine receptors defines a subclass of second generation antipsychotics that promotes drug tolerance

This study identifies some second generation antipsychotics (SGAs) as arrestin-3 agonists at D3 dopamine receptors, showing that chronic use leads to receptor degradation and altered drug efficacy.

Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells

The paper shows that loss of NaV1.2 sodium channels in pyramidal neurons leads to hyperexcitability and seizures despite reduced action potential size and speed.

The autism-associated gene Scn2a plays an essential role in synaptic stability and learning

This study shows that the autism-associated gene Scn2a is critical for synaptic stability and learning by regulating dendritic excitability and synaptic function in neurons.