Elinor Lewis

Acute in vivo proximity labeling for membrane targeted proteomics in neuronal circuits

The paper develops membrane-targeted TurboID variants for in vivo proteomics in neuronal circuits, identifying subcellular proteins and their changes during acute drug exposure.

D3 dopamine receptors implicate a striatal neuronal subtype in the aversive effects of the antipsychotic drug quetiapine

This study identifies D3R-expressing neurons in the NAc as mediators of quetiapine's aversive effects, showing that chronic treatment reduces this aversion.

Nucleus accumbens sub-regions experience distinct dopamine release responses following acute and chronic morphine exposure

This study examines dopamine release in the medial and lateral shell of the nucleus accumbens in response to acute and chronic morphine exposure in mice, revealing distinct responses between the two sub-regions.

Arrestin-3 agonism at D3 dopamine receptors defines a subclass of second generation antipsychotics that promotes drug tolerance

This study identifies some second generation antipsychotics (SGAs) as arrestin-3 agonists at D3 dopamine receptors, showing that chronic use leads to receptor degradation and altered drug efficacy.