Nociceptor to macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth
Victor Fattori, Tiago H. Zaninelli, Fernanda Soares Rasquel-Oliveira, Olivia K. Heintz, Ashish Kumar Jain, Liang Sun, Maya L. Seshan, Daniëlle Peterse, Anne E. Lindholm, Raymond M. Anchan, Waldiceu Aparecido Verri Jr, Michael S. Rogers
This study identifies CGRP/RAMP1 signaling as a driver of endometriosis pain and lesion growth, showing that blocking this pathway reduces pain and lesion size in mice.
bioRxiv · Aug 28, 2023 · PreprintNeuroscience