M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy with Comorbid Traits
Soledad Ochoa, Fernanda Soares Rasquel-Oliveira, Brett David McKinnon, Marcela Haro, Sugarniya Subramaniam, Pak Hin Yu, Simon G. Coetzee, Michael S. Anglesio, Kelly Nicole Wright, Raanan Meyer, Anne E. Porter, Caroline E. Gargett, Sally Mortlock, Grant W. Montgomery, Michael S. Rogers, Kate Lawrenson
This study identifies M2 macrophages and IL1 signaling as key mediators of endometriosis risk and shows their pleiotropic role in comorbid traits.
Advanced Science · Sep 12, 2025Peer-reviewedImmunology