Spatially resolved transcriptome profiles of mammalian kidneys illustrate the molecular complexity of functional nephron segments, cell-to-cell interactions and genetic variants.
Arti M. Raghubar, Duy T. Pham, Xiao Tan, Laura F. Grice, Joanna Crawford, Pui Yeng Lam, Stacey B. Andersen, Sohye Yoon, Monica Suet Ying Ng, Siok Min Teoh, Samuel E. Holland, Anne Stewart, Leo P. Francis, Alexander N. Combes, Andrew J. Kassianos, , Andrew John Mallett
This study uses spatial transcriptomics to analyze human and mouse kidney tissues, identifying gene expression patterns, nephron segments, cell interactions, and genetic variants while preserving spatial context.
bioRxiv · Sep 29, 2020 · PreprintMolecular Biology