Andrew John Mallett

The paper identifies 354,937 novel lncRNAs across 13 cancer types using single-cell and spatial transcriptomics, revealing their cell-type specificity, spatial distribution, and potential functional roles.

The paper introduces Cornetto, a method using targeted long-read sequencing to improve genome assembly quality and completeness, particularly for challenging regions and sample types.

The paper develops an automated tool for reanalyzing genomic data in rare disease cohorts, showing improved diagnostic yields through iterative reanalysis.

The paper shows that forming nephrons maintain the nephrogenic niche via paracrine BMP4 signaling controlled by Wnt4, supporting a revised model of kidney development.

This study uses spatial transcriptomics to analyze human and mouse kidney tissues, identifying gene expression patterns, nephron segments, cell interactions, and genetic variants while preserving spatial context.

This study performs GWAS on medication-use data from 320,000 UK Biobank participants, identifying 505 genetic loci and linking them to 16 known therapeutic targets.