Alexander N. Combes

This study compares iPSC-derived kidney organoids, adult tubuloids, and fetal tubuloids with human kidneys using RNA sequencing to identify differences in gene expression and injury response.

The paper shows that forming nephrons maintain the nephrogenic niche via paracrine BMP4 signaling controlled by Wnt4, supporting a revised model of kidney development.

This study uses human kidney organoids to model hypoxic injury and maladaptive repair, identifying molecular and metabolic changes associated with AKI and CKD progression.

This study uses spatial transcriptomics to analyze human and mouse kidney tissues, identifying gene expression patterns, nephron segments, cell interactions, and genetic variants while preserving spatial context.

The paper uses single-cell RNA-seq to analyze developing mouse kidney and human kidney organoids, identifying cell clusters and revealing insights into kidney development and organoid maturation.

The paper demonstrates the use of bioprinted kidney organoids for high content drug screening, showing reproducibility and response to doxorubicin toxicity.

This paper introduces an agent-based model of kidney branching morphogenesis and uses Bayesian inference to show that growth factor-dependent cell division is essential for branching.