Laura F. Grice

Gp130 Orchestrates a Bidirectional Neuron-Microglia Circuit for neuroprotection

This study identifies gp130 as a key receptor for a bidirectional neuron-microglia circuit that enhances neuroprotection after CNS injury.

Integrating 12 Spatial and Single Cell Technologies to Characterise Tumour Neighbourhoods and Cellular Interactions in three Skin Cancer Types

The paper integrates 12 spatial and single-cell technologies to analyze cellular interactions and signatures in three skin cancers, identifying key therapeutic targets and genetic associations.

stLearn: integrating spatial location, tissue morphology and gene expression to find cell types, cell-cell interactions and spatial trajectories within undissociated tissues

A robust Platform for Integrative Spatial Multi-omics Analysis to Map Immune Responses to SARS-CoV-2 infection in Lung Tissues

This paper develops a spatial multi-omics platform to analyze immune responses in SARS-CoV-2-infected lung tissues, revealing macrophage infiltration and spatial heterogeneity in cytokine and interferon signaling.

Spatially resolved transcriptome profiles of mammalian kidneys illustrate the molecular complexity of functional nephron segments, cell-to-cell interactions and genetic variants.

This study uses spatial transcriptomics to analyze human and mouse kidney tissues, identifying gene expression patterns, nephron segments, cell interactions, and genetic variants while preserving spatial context.