IGS38, a lncRNA from the human rDNA intergenic spacer, regulates rRNA transcription by altering rDNA chromatin organisation and activating the transcription machinery
Kanwal Tariq, Mareike Polenkowski, Jaclyn E. Quin, Anaswara Sugathan, Signe Skog, Stefanie Jakobsson, Elin Enervald, Anne von Euler, Anita Öst, Neus Visa, Ann‐Kristin Östlund Farrants
This paper identifies IGS38, a lncRNA that enhances rRNA transcription by altering chromatin structure and promoting RNA polymerase I promoter escape.
bioRxiv · May 4, 2026 · PreprintCell Biology