Shruti Jain

This paper shows that DIS3's 3-5 exoribonuclease activity degrades backtracked RNA, resolving stalled RNAPII complexes and enabling transcription elongation.

The paper designs novel cytokines by fusing computationally generated receptor-binding domains, identifying several that activate signaling pathways and have specific biological effects.

The paper identifies the origin of plasmid pMF1 in Myxococcus fulvus 124B02, showing it originated from a chromosomal segment of M. stipitatus, and confirms M. stipitatus CYD1 as a novel species.

The paper shows the exosome degrades chromatin-associated RNAs and helps maintain chromatin homeostasis by regulating repetitive sequences and centromere organization.

This study identifies DNA sequences that dIno80 binds with high specificity and shows this interaction positively regulates transcription.

This paper shows dIno80 interacts with PREs in Drosophila and can rescue pho mutant lethality, suggesting it functions in cellular memory through non-canonical complexes.