Substrate stiffness regulates triple-negative breast cancer signaling through CXCR4 receptor dynamics
Kenneth K. Y. Ho, Johanna M. Buschhaus, Anne Zhang, Alyssa C. Cutter, Brock A. Humphries, Gary D. Luker
This study shows that substrate stiffness affects CXCR4 and EGFR expression and signaling in TNBC cells, promoting Akt and ERK activation and migration.
Scientific Reports · Aug 13, 2025Peer-reviewedCancer Biology