SARS-CoV-2 evolution in the absence of selective immune pressures, results in antibody resistance, interferon suppression and phenotypic differences by lineage
Julian Willett, Annie Gravel, Isabelle Dubuc, Leslie Gudimard, Ana Cláudia dos Santos Pereira Andrade, Émile Lacasse, Paul R. Fortin, Ju‐Ling Liu, Jose Avila Cervantes, José Héctor Gálvez, Haig Hugo Vrej Djambazian, Melissa Zwaig, Anne-Marie Roy, Sally Lee, Shu‐Huang Chen, , Louis Flamand
This study shows that SARS-CoV-2 evolves in the absence of immune pressure, leading to antibody resistance, interferon suppression, and lineage-specific phenotypic changes.
bioRxiv · Jan 16, 2023 · PreprintGenetics