Leslie Gudimard

SARS-CoV-2 Nsp2 reprograms host immunity to drive pathogenic inflammation

This study shows that SARS-CoV-2 Nsp2 drives immunopathology by reprogramming host immune responses, leading to more severe inflammation compared to its deletion mutant.

Delayed viral clearance and altered inflammatory responses resulted in increased severity of SARS-CoV-2 infection in aged mice.

This study compares SARS-CoV-2 infection in young and aged mice, finding delayed viral clearance and weakened immune responses in older mice, leading to increased disease severity.

SARS-CoV-2 evolution in the absence of selective immune pressures, results in antibody resistance, interferon suppression and phenotypic differences by lineage

This study shows that SARS-CoV-2 evolves in the absence of immune pressure, leading to antibody resistance, interferon suppression, and lineage-specific phenotypic changes.