Isabelle Dubuc

This study identifies IL-17RD as a negative regulator of RIG-I-like receptor-dependent antiviral immunity, showing it limits SARS-CoV-2-induced lung inflammation.

This study shows that SARS-CoV-2 Nsp2 drives immunopathology by reprogramming host immune responses, leading to more severe inflammation compared to its deletion mutant.

The paper benchmarks SARS-CoV-2 whole genome sequencing methods and introduces an improved ARTIC-Amp protocol for better coverage in low RNA samples.

This study compares SARS-CoV-2 infection in young and aged mice, finding delayed viral clearance and weakened immune responses in older mice, leading to increased disease severity.

This study shows that SARS-CoV-2 evolves in the absence of immune pressure, leading to antibody resistance, interferon suppression, and lineage-specific phenotypic changes.

This study identifies tissue-specific RNA expression of integrated HHV-6A/B in vivo and links it to increased antibody responses against specific viral antigens.