Émile Lacasse

This study identifies IL-17RD as a negative regulator of RIG-I-like receptor-dependent antiviral immunity, showing it limits SARS-CoV-2-induced lung inflammation.

This study shows that SARS-CoV-2 Nsp2 drives immunopathology by reprogramming host immune responses, leading to more severe inflammation compared to its deletion mutant.

This study compares SARS-CoV-2 infection in young and aged mice, finding delayed viral clearance and weakened immune responses in older mice, leading to increased disease severity.

This study shows that SARS-CoV-2 evolves in the absence of immune pressure, leading to antibody resistance, interferon suppression, and lineage-specific phenotypic changes.