HSF2BP Negatively Regulates Homologous Recombination in DNA Interstrand Crosslink Repair in Human Cells by Direct Interaction With BRCA2
Inger Brandsma, Koichi Sato, Sari E. van Rossum-Fikkert, Marcel Reuter, Hanny Odijk, Nicole S. Verkaik, Nathalie van den Tempel, Anneke B. Oostra, Dick H. W. Dekkers, Karel Bezstarosti, Jeroen Demmers, Joyce H.G. Lebbink, Claire Wyman, Josephine C. Dorsman, Dik C. van Gent, , Alex N. Zelensky
This study identifies HSF2BP as a regulator of homologous recombination in ICL repair by interacting with BRCA2, showing its role in genomic instability and cancer.
bioRxiv · Oct 16, 2018 · PreprintMolecular Biology