Author

Hanny Odijk

Erasmus MC

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Roland KanaariD· 4 shared Alex N. ZelenskyiD· 2 shared Claire WymaniD· 2 shared Ingrid M.B.H. van de LaariD· 2 shared Ingrid van der PluijmiD· 2 shared Jeroen EssersiD· 2 shared Nathalie P. Vroegindeweij-de WagenaariD· 2 shared Anneke B. Oostra· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersMolecular Biology

Roland KanaarORCID

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4 papers

Recent·Most cited

Generation and characterization of Induced Pluripotent Stem Cell models with SMAD3 mutations to study the molecular mechanism of Loeys-Dietz Syndrome Type III aneurysm formation

Nathalie P. Vroegindeweij-de Wagenaar, Janette van der Linden, Hanny Odijk, Matthijs Snelders, Ingrid M.B.H. van de Laar, Roland Kanaar, Ingrid van der Pluijm, Jeroen Essers

This study generates and characterizes induced pluripotent stem cell models with SMAD3 mutations to investigate LDS3 aneurysm formation mechanisms.

bioRxiv · Aug 26, 2025 · PreprintMolecular Biology

Functional analysis of cell lines derived from SMAD3-related Loeys-Dietz Syndrome patients provides insights into genotype-phenotype relations

Nathalie P. Vroegindeweij-de Wagenaar, Lisa M. van den Bersselaar, Hanny Odijk, Sanne J. M. Stefens, Dieter Peter Reinhardt, Jolien W. Roos‐Hesselink, Roland Kanaar, Judith M. A. Verhagen, Hennie T. Brüggenwirth, Ingrid M.B.H. van de Laar, Ingrid van der Pluijm, Jeroen Essers

This study investigates the functional impact of SMAD3 variants in patient-derived cells, showing distinct effects of dominant negative and haploinsufficient variants on disease manifestations and age of onset.

Human Molecular Genetics · Mar 6, 2024Peer-reviewedGenetics

Role of BRCA2 DNA-binding and C-terminal domain on its mobility and conformation in DNA repair

Maarten W. Paul, Arshdeep Sidhu, Yongxin Liang, Sarah E. van Rossum-Fikkert, Hanny Odijk, Alex N. Zelensky, Roland Kanaar, Claire Wyman

This study examines how BRCA2's DNA-binding and C-terminal domains affect its mobility and conformation during DNA repair, showing that C-terminal deletions do not significantly impact mobility but impair architectural changes and homologous recombination function.

eLife · Jul 13, 2021Peer-reviewedMolecular Biology

HSF2BP Negatively Regulates Homologous Recombination in DNA Interstrand Crosslink Repair in Human Cells by Direct Interaction With BRCA2

Inger Brandsma, Koichi Sato, Sari E. van Rossum-Fikkert, Marcel Reuter, Hanny Odijk, Nicole S. Verkaik, Nathalie van den Tempel, Anneke B. Oostra, Dick H. W. Dekkers, Karel Bezstarosti, Jeroen Demmers, Joyce H.G. Lebbink, Claire Wyman, Josephine C. Dorsman, Dik C. van Gent, , Alex N. Zelensky

This study identifies HSF2BP as a regulator of homologous recombination in ICL repair by interacting with BRCA2, showing its role in genomic instability and cancer.

bioRxiv · Oct 16, 2018 · PreprintMolecular Biology