Author

Karel Bezstarosti

Erasmus MC

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3 Biochemistry· 2 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

Jeroen DemmersiD· 7 shared Dick H. W. DekkersiD· 5 shared Wouter A. S. DoffiD· 3 shared Ayestha SijmiD· 2 shared C. Peter VerrijzeriD· 2 shared Jan A. van der KnaapiD· 2 shared Joyce Wolf van der MeeriD· 2 shared Alex N. ZelenskyiD· 1 shared

Activity by Year

2018-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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7 shared papersMolecular Biology

Jeroen DemmersORCID

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Author profile →

7 papers

Recent·Most cited

A role for tubulin in cellular quality control and proteostasis

Sreya Basu, Nuo Yu, Riccardo Viscusi, Wouter A. S. Doff, Mirjam C. G. N. van den Hout, Wilfred F. J. van IJcken, Karel Bezstarosti, Dick H. W. Dekkers, Jeroen Demmers, Niels Galjart

This study shows that tubulin overexpression causes proteostasis defects and replication stress by disrupting mitochondrial translation and cell cycle regulation.

bioRxiv · Jul 24, 2026 · PreprintCell Biology

Proteome-wide ubiquitinome profiling reveals substrate-specific dynamics within the USP7 network

Joyce Wolf van der Meer, Jan A. van der Knaap, Ayestha Sijm, Karel Bezstarosti, Dick H. W. Dekkers, Wouter A. S. Doff, Jeroen Demmers, C. Peter Verrijzer

This study uses proteomics to show that USP7's deubiquitylation effects are substrate-specific, revealing its role in neurodevelopment and tumor suppression.

Molecular & Cellular Proteomics · Jun 16, 2026Peer-reviewedBiochemistry

Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1

Joyce Wolf van der Meer, Axelle Larue, Jan A. van der Knaap, Gillian E. Chalkley, Ayestha Sijm, Leila Beikmohammadi, Elena N. Kozhevnikova, Aniek van der Vaart, Ben C. Tilly, Karel Bezstarosti, Dick H. W. Dekkers, Wouter A. S. Doff, P. Jantine van de Wetering-Tieleman, Kristina Lanko, Tahsin Stefan Barakat, , C. Peter Verrijzer

The paper identifies USP7's role in neuronal differentiation by regulating BCOR-ncPRC1.1, revealing a shared epigenetic network in neurodevelopmental disorders.

Genes & Development · Mar 1, 2025Peer-reviewedMolecular Biology

Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53

Kim Wendrich, Kai Gallant, Sarah Recknagel, Stavroula Petroulia, Nafizul Haque Kazi, Jan André Hane, Siska Führer, Karel Bezstarosti, Rachel O’Dea, Jeroen Demmers, Malte Gersch

This study identifies USP53 and USP54 as active deubiquitinases specific for K63-linked polyubiquitin, revealing their role in regulating tricellular junctions and correcting previous annotations of them as pseudo-enzymes.

Nature Chemical Biology · Nov 25, 2024Peer-reviewedBiochemistry

Simultaneous loss of CAMK2A and CAMK2B reveals endogenous in vivo substrates

Pomme M.F. Rigter, Karel Bezstarosti, Oguz Can Koc, Tyler L. Perfitt, Jeroen Demmers, Roger J. Colbran, Margaret M. Stratton, Ype Elgersma, Geeske M. van Woerden

The paper identifies novel endogenous CAMK2 substrates by analyzing phosphoproteomic data from double knockout mice.

bioRxiv · Nov 17, 2024 · PreprintNeuroscience

STK19 drives Transcription-Coupled Repair by stimulating repair complex stability, Pol II ubiquitylation and TFIIH recruitment

Anisha R. Ramadhin, Shun-Hsiao Lee, Di Zhou, Anita P. T. Salmazo, Camila Gonzalo-Hansen, Marjolein van Sluis, Cindy M.A. Blom, Roel C. Janssens, Anja Raams, Dick H. W. Dekkers, Karel Bezstarosti, Dea Slade, Wim Vermeulen, Alex Pines, Jeroen Demmers, , Jurgen A. F. Marteijn

This study identifies STK19 as a critical factor in transcription-coupled nucleotide excision repair by stabilizing the repair complex and promoting Pol II ubiquitylation and TFIIH recruitment.

bioRxiv · Jul 22, 2024 · PreprintMolecular Biology

HSF2BP Negatively Regulates Homologous Recombination in DNA Interstrand Crosslink Repair in Human Cells by Direct Interaction With BRCA2

Inger Brandsma, Koichi Sato, Sari E. van Rossum-Fikkert, Marcel Reuter, Hanny Odijk, Nicole S. Verkaik, Nathalie van den Tempel, Anneke B. Oostra, Dick H. W. Dekkers, Karel Bezstarosti, Jeroen Demmers, Joyce H.G. Lebbink, Claire Wyman, Josephine C. Dorsman, Dik C. van Gent, , Alex N. Zelensky

This study identifies HSF2BP as a regulator of homologous recombination in ICL repair by interacting with BRCA2, showing its role in genomic instability and cancer.

bioRxiv · Oct 16, 2018 · PreprintMolecular Biology