Claire Wyman

This study examines how BRCA2's DNA-binding and C-terminal domains affect its mobility and conformation during DNA repair, showing that C-terminal deletions do not significantly impact mobility but impair architectural changes and homologous recombination function.

This study identifies HSF2BP as a regulator of homologous recombination in ICL repair by interacting with BRCA2, showing its role in genomic instability and cancer.