Functionality of BRCA1 supports the survival of prostate cancer cells during the development of castration resistance
Saiganesh Sriraman, Verneri Virtanen, Antti Kukkula, Mervi Toriseva, Anne Rokka, Anni Lumiainen, Johanna K. Ahlskog, Gun West, Matti H. POUTANEN, Pekka Taimen, Maria Sundvall
This study shows that BRCA1 supports prostate cancer cell survival during castration resistance by modulating mTOR signaling and NRF2-mediated antioxidant processes.
bioRxiv · Jun 19, 2024 · PreprintCancer Biology