Saiganesh Sriraman

This study identifies SUMOylation as a therapeutic target in high-risk neuroblastoma, showing that SUMO pathway inhibitors like TAK-981 reduce tumor growth and are effective in combination with other therapies.

This study identifies a regulatory feedback loop between LRRK2 and PP2A phosphatases in Parkinson's disease, showing that LRRK2 phosphorylates PP2A to disrupt its function and contribute to neuronal death.

This study shows that BRCA1 supports prostate cancer cell survival during castration resistance by modulating mTOR signaling and NRF2-mediated antioxidant processes.