Ubiquitin-specific peptidase 20 constrains endothelial cell activation and angiogenic sprouting through NF-κB inhibition
Bipradas Roy, Jiao‐Hui Wu, Richard Jiang, Annie Bao, Neil J. Freedman, Sudha K. Shenoy
This study shows that USP20 inhibits NF-κB signaling in endothelial cells, reducing angiogenesis, and that phosphorylation of USP20 at Ser334 enhances NF-κB activity and promotes angiogenic sprouting.
bioRxiv · May 20, 2025 · PreprintCancer Biology