Cancer BiologybioRxivPreprint
Ubiquitin-specific peptidase 20 constrains endothelial cell activation and angiogenic sprouting through NF-κB inhibition
Bipradas Roy, Jiao‐Hui Wu, Richard Jiang…·Sudha K. Shenoy
This study shows that USP20 inhibits NF-κB signaling in endothelial cells, reducing angiogenesis, and that phosphorylation of USP20 at Ser334 enhances NF-κB activity and promotes angiogenic sprouting.
DOI 10.1101/2025.05.20.655129