Author

Neil J. Freedman

Duke UniversityORCID 0000-0002-8593-8676Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Jiao‐Hui Wu· 2 shared Annie Bao· 1 shared Bipradas RoyiD· 1 shared Brittany A. ElliottiD· 1 shared Christopher L. HolleyiD· 1 shared Erik J. SoderblomiD· 1 shared Greg M. WaittiD· 1 shared Kamie P. SnowiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMolecular Biology

Jiao‐Hui Wu

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2 papers

Recent·Most cited

Rpl13a snoRNAs Downregulate Smooth Muscle Cell COX4I2 and Promote Neointimal Hyperplasia

Brittany A. Elliott, Lisheng Zhang, Jiao‐Hui Wu, Pei‐Chen Wu, Xinhe Yin, Erik J. Soderblom, Kamie P. Snow, Greg M. Waitt, Christopher L. Holley, Neil J. Freedman

This study shows that Rpl13a snoRNAs increase SMC ROS levels by reducing COX4I2 expression, leading to neointimal hyperplasia.

bioRxiv · Jul 23, 2025 · PreprintMolecular Biology

Ubiquitin-specific peptidase 20 constrains endothelial cell activation and angiogenic sprouting through NF-κB inhibition

Bipradas Roy, Jiao‐Hui Wu, Richard Jiang, Annie Bao, Neil J. Freedman, Sudha K. Shenoy

This study shows that USP20 inhibits NF-κB signaling in endothelial cells, reducing angiogenesis, and that phosphorylation of USP20 at Ser334 enhances NF-κB activity and promotes angiogenic sprouting.

bioRxiv · May 20, 2025 · PreprintCancer Biology