Wasf1 deletion attenuates tau hyperphosphorylation, microglial state transition, and cognitive deficits in P301S tau mice
Clara Berdasco, Woo-Hyun Cho, Jordan Lee, Annu Annu, José Henrique Ledo, Yu Young Jeong, Yoon-Seong Kim, Steven S. An, Yoshiaki Tanaka, Jung-Hyuck Ahn, Yong Kim
This study shows that deleting Wasf1 in P301S tau mice reduces tau hyperphosphorylation, improves cognition, and restores microglial function.
bioRxiv · Jan 15, 2026 · PreprintNeuroscience