Yoshiaki Tanaka

This paper reports the first derivation of elephant induced pluripotent stem cells (emiPSCs) using a modified reprogramming protocol that inhibits TP53 expansion genes.

This study shows that deleting Wasf1 in P301S tau mice reduces tau hyperphosphorylation, improves cognition, and restores microglial function.

This study generates therapeutic endothelial cells from fibroblasts using non-integrating adenoviral ETV2 and enhances their long-term engraftment with nanomatrix delivery, showing sustained vascular regeneration in a mouse model.

The paper identifies unique molecular responses of CAR-T cells in solid tumors through single-cell transcriptomic analysis, revealing immunosuppressive subpopulations and PD-1-independent exhaustion-like features.

This study shows FOXK1 O-GlcNAcylation regulates the E2F pathway, promoting cell proliferation and oncogenesis by modulating chromatin structure and transcriptional activity.

The paper evaluates computational methods for predicting cell type-specific enhancers in the mouse cortex using in vivo validation data and finds that open chromatin and sequence models improve prediction accuracy.

This paper introduces scIDST, a weakly-supervised deep learning method to infer disease progressive stages in single-cell transcriptomics, revealing disease-relevant gene expression patterns not detectable by standard comparisons.

This study identifies a FOXA1/SPDEF co-regulatory axis that drives ERBB2 expression and suppresses EMT in HER2+ breast cancer, maintaining luminal identity and serving as a therapeutic target.

This study investigates how the dyslexia-associated gene KIAA0319 regulates cell cycle during human neuroepithelium development, linking it to reading disability through effects on neuronal progenitor cells.