José Henrique Ledo

Efficacy of glucocorticoid modulator PT150 as a weight loss strategy

This study evaluates PT150, a GR antagonist, as a weight loss strategy in combination with semaglutide in diet-induced obese mice, showing improved weight reduction and setpoint maintenance.

Functional border-associated macrophages limit Alzheimer's Disease progression

This study shows that border-associated macrophages (BAM) are critical in limiting Alzheimer's Disease progression by clearing beta-amyloid, and their loss accelerates disease pathology.

Wasf1 deletion attenuates tau hyperphosphorylation, microglial state transition, and cognitive deficits in P301S tau mice

This study shows that deleting Wasf1 in P301S tau mice reduces tau hyperphosphorylation, improves cognition, and restores microglial function.

Molecular and cellular adaptations in hippocampal parvalbumin neurons mediate behavioral responses to chronic social stress

A Developmental Role for Microglial Presenilin 1 in Memory

This study shows that deleting Presenilin 1 in microglia during development enhances memory and neuronal activity in mice, with effects dependent on GluN2B and mitigating Alzheimer's symptoms.