Quantitative contributions of hepatic and renal organic cation transporters to the clinical pharmacokinetic cimetidine-metformin interaction
Anoud Sameer Ailabouni, Dilip Kumar Singh, Aarzoo Thakur, Erin C. Boone, Andrea Gaedigk, Mary F. Paine, Bhagwat Prasad
This study investigates how cimetidine affects metformin's pharmacokinetics by inhibiting OCT1 and OCT2, showing increased plasma exposure and reduced renal clearance.
Clinical Pharmacology & Therapeutics · Mar 17, 2025Peer-reviewedPharmacology & Toxicology