Author

Andrea Gaedigk

Children's Mercy HospitalORCID 0000-0001-6968-1893Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:clinical cohort / trial· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Aarzoo ThakuriD· 1 shared Anoud Sameer Ailabouni· 1 shared Bhagwat PrasadiD· 1 shared Dilip Kumar SinghiD· 1 shared Erica L. WoodahliD· 1 shared Erin C. BooneiD· 1 shared Gregory McInnesiD· 1 shared Katrin SangkuhliD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

Aarzoo ThakurORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyClinical Pharmacology & TherapeuticsPeer-reviewedMar 17, 2025

Quantitative contributions of hepatic and renal organic cation transporters to the clinical pharmacokinetic cimetidine-metformin interaction

Anoud Sameer Ailabouni, Dilip Kumar Singh, Aarzoo Thakur…·Bhagwat Prasad

This study investigates how cimetidine affects metformin's pharmacokinetics by inhibiting OCT1 and OCT2, showing increased plasma exposure and reduced renal clearance.

11 citationstop 4%

humanclinical cohort / trial

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BioinformaticsPLoS Computational BiologyPeer-reviewedNov 2, 2020

Transfer learning enables prediction of CYP2D6 haplotype function

Gregory McInnes, Rachel Dalton, Katrin Sangkuhl…·Erica L. Woodahl

This paper introduces a deep learning model, Hubble.2D6, to predict CYP2D6 haplotype function with 88% accuracy, aiding in drug response prediction.

55 citationstop 2%

humandeep learning

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