GIRK Channel Loss of Function Increases Dendritic Excitability in a Mouse Model of GNB1 Encephalopathy
Samuel Gritz, Anshul Voleti, Matthew S. Scarnati, Alessandro R. Galloni, Aaron D. Milstein
This study shows that a GNB1 mutation impairs GIRK channel function in mice, leading to increased dendritic excitability and seizure susceptibility, which can be reversed by a GIRK activator.
bioRxiv · Aug 14, 2026 · PreprintNeuroscience