Aaron D. Milstein

GIRK Channel Loss of Function Increases Dendritic Excitability in a Mouse Model of GNB1 Encephalopathy

This study shows that a GNB1 mutation impairs GIRK channel function in mice, leading to increased dendritic excitability and seizure susceptibility, which can be reversed by a GIRK activator.

The Importance of Synchrony in the Neural Control of Movement

This study shows that neural synchrony, not firing rate, is critical for movement generation by stimulating a small number of motor cortex neurons.

Hippocampal Place Cells with NMDARs Do Not Require Excitation and Inhibition to Be Reciprocally Tuned

The paper shows that NMDARs allow place cells to maintain spatial selectivity without requiring changes in inhibitory inputs.

Cellular and subcellular specialization enables biology-constrained deep learning

This paper develops a biology-compatible deep learning algorithm that uses specialized neuronal cell types and compartmentalized signaling to improve image classification.

Offline memory replay in recurrent neuronal networks emerges from constraints on online dynamics

The paper shows that constraints on neural network dynamics in a hippocampal model enable flexible offline memory replay of sensory sequences.

Bidirectional synaptic plasticity rapidly modifies hippocampal representations

This study shows that bidirectional synaptic plasticity modifies hippocampal place fields by adjusting synaptic weights based on temporal proximity and current synaptic strength.

Towards a general framework for modeling large-scale biophysical neuronal networks: a full-scale computational model of the rat dentate gyrus

The paper introduces a computational framework for building and simulating large-scale biophysical neuronal networks, demonstrating its application to a rat dentate gyrus model with biologically plausible activity.