Multi-region whole-genome and transcriptomic profiling uncovers plastic, subclone-linked cell states in high-grade diffuse astrocytomas
Serafiina Ohlsbom, S Mäntylä, Reetta Nätkin, Ismaïl Hermelo, Anssi Nurminen, Aliisa M. Tiihonen, Iida Salonen, Elisa M. Vuorinen, Kristiina Nordfors, Hannu K. Haapasalo, Kirsi J. Rautajoki, Joonas A. Haapasalo, Matti Nykter
This study uses multi-region whole-genome and transcriptomic profiling to show how genomic backbones and regional transcriptional plasticity drive phenotypic diversity in high-grade astrocytomas.
bioRxiv · Aug 11, 2026 · PreprintCancer Biology