Author

Kirsi J. Rautajoki

Tampere UniversityORCID 0000-0001-6549-7810Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2

Frequent Co-Authors

Matti NykteriD· 4 shared Aliisa M. TiihoneniD· 3 shared Iida SaloneniD· 3 shared Joonas A. HaapasaloiD· 3 shared Hannu K. HaapasaloiD· 2 shared Ismaïl HermeloiD· 2 shared Juha KesseliiD· 2 shared Miina HoikkaiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Matti NykterORCID

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 11, 2026

Multi-region whole-genome and transcriptomic profiling uncovers plastic, subclone-linked cell states in high-grade diffuse astrocytomas

Serafiina Ohlsbom, S Mäntylä, Reetta Nätkin…·Matti Nykter

This study uses multi-region whole-genome and transcriptomic profiling to show how genomic backbones and regional transcriptional plasticity drive phenotypic diversity in high-grade astrocytomas.

DOI 10.64898/2026.08.11.743949

humanwhole-genome sequencing

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Cancer BiologybioRxivPreprintFeb 28, 2026

Hypoxia and Associated Acidosis Generate Cell-Type Specific Myeloid Responses in Glioblastoma

Aliisa M. Tiihonen, Iida Salonen, Iina Koivisto…·Kirsi J. Rautajoki

The paper investigates how hypoxia and acidosis influence myeloid cell responses in glioblastoma, revealing distinct metabolic adaptations in macrophages versus microglia.

1 citation

humanscRNA-seq

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Cancer BiologybioRxivPreprintSep 30, 2025

Integrative multi-modal analysis reveals the contribution of noncoding RNAs to post-treatment progression of IDH-mutant astrocytomas

Anja Hartewig, Serafiina Jaatinen, Matti Annala…·Kirsi J. Rautajoki

The paper identifies progression-related noncoding RNAs in IDH-mutant astrocytomas after treatment, linking them to cell cycle, ECM, and neural differentiation processes.

DOI 10.1101/2025.09.30.679694

humanbulk RNA-seq

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Cancer BiologyNature CommunicationsPeer-reviewedNov 16, 2024

Immunosuppression in the prostate tumor microenvironment is tied to androgen deprivation therapy-resistant club-like cells

Antti Kiviaho, Sini K. Eerola, Heini M. L. Kallio…·Matti Nykter

The paper identifies club-like cells in the prostate tumor microenvironment that contribute to androgen deprivation therapy resistance through immune suppression.

104 citationstop 1%

humanscRNA-seq

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