Author

Joonas A. Haapasalo

Tampere University HospitalORCID 0000-0002-6468-4937Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Kirsi J. RautajokiiD· 3 shared Matti NykteriD· 3 shared Aliisa M. TiihoneniD· 2 shared Hannu K. HaapasaloiD· 2 shared Iida SaloneniD· 2 shared S MäntyläiD· 2 shared Serafiina JaatineniD· 2 shared A S RitamäkiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

Kirsi J. RautajokiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Multi-region whole-genome and transcriptomic profiling uncovers plastic, subclone-linked cell states in high-grade diffuse astrocytomas

Serafiina Ohlsbom, S Mäntylä, Reetta Nätkin, Ismaïl Hermelo, Anssi Nurminen, Aliisa M. Tiihonen, Iida Salonen, Elisa M. Vuorinen, Kristiina Nordfors, Hannu K. Haapasalo, Kirsi J. Rautajoki, Joonas A. Haapasalo, Matti Nykter

This study uses multi-region whole-genome and transcriptomic profiling to show how genomic backbones and regional transcriptional plasticity drive phenotypic diversity in high-grade astrocytomas.

bioRxiv · Aug 11, 2026 · PreprintCancer Biology

Hypoxia and Associated Acidosis Generate Cell-Type Specific Myeloid Responses in Glioblastoma

Aliisa M. Tiihonen, Iida Salonen, Iina Koivisto, A S Ritamäki, Serafiina Jaatinen, Tanja Hyvärinen, Johanna Tilvis, Joose Kreutzer, Göktuğ Karabiyik, S Mäntylä, Maryam Mohammadlou, Miina Hoikka, Masi Valkonen, Jürgen Beck, Roland Roelz, , Kirsi J. Rautajoki

The paper investigates how hypoxia and acidosis influence myeloid cell responses in glioblastoma, revealing distinct metabolic adaptations in macrophages versus microglia.

bioRxiv · Feb 28, 2026 · PreprintCancer Biology

Integrative multi-modal analysis reveals the contribution of noncoding RNAs to post-treatment progression of IDH-mutant astrocytomas

Anja Hartewig, Serafiina Jaatinen, Matti Annala, Joonas A. Haapasalo, Wei Zhang, Hannu Haapasalo, Matti Nykter, Xin Lai, Kirsi J. Rautajoki

The paper identifies progression-related noncoding RNAs in IDH-mutant astrocytomas after treatment, linking them to cell cycle, ECM, and neural differentiation processes.

bioRxiv · Sep 30, 2025 · PreprintCancer Biology