Smad4 Loss in the Mouse Intestinal Epithelium Alleviates the Pathological Fibrotic Response to Injury in the Colon
Zahra Hashemi, Thompson Hui, Alex Wu, Dahlia Matouba, Steven Zukowski, Shima Nejati, Crystal Lim, Julianna Bruzzese, Kyle Seabold, Connor Mills, Cindy Lin, Kylee Wrath, Haoyu Wang, Hongjun Wang, Michael P. Verzi, Ansu Perekatt
This study shows that Smad4 loss in the mouse intestinal epithelium reduces pathological fibrosis and improves mucosal repair after DSS-induced injury.
bioRxiv · Mar 8, 2024 · PreprintCell Biology