Dedifferentiation-Driven Oncogenic Stemness Promotes Tumor-Sustaining Adaptability in the Intestinal Epithelium
Kylee Zgeib, Thompson Hui, Simon Garcia, Zahra Hashemi, Shima Nejati, Amartya Singh, Atharva Inamdar, Crystal Lim, Dahlia Matouba, Christina Li, Binfeng Lu, Ansu O. Perekatt
This study shows dedifferentiation-derived oncogenic stem cells sustain intestinal tumorigenesis more effectively than mutant stem cells, with aberrant Notch signaling and metabolic plasticity contributing to tumor growth.
Cell Death and Disease · Apr 17, 2026Peer-reviewedCancer Biology