Cancer BiologyCell Death and DiseasePeer-reviewed
Dedifferentiation-Driven Oncogenic Stemness Promotes Tumor-Sustaining Adaptability in the Intestinal Epithelium
Kylee Zgeib, Thompson Hui, Simon Garcia…·Ansu O. Perekatt
This study shows dedifferentiation-derived oncogenic stem cells sustain intestinal tumorigenesis more effectively than mutant stem cells, with aberrant Notch signaling and metabolic plasticity contributing to tumor growth.