Highly sensitive mapping of in vitro type II topoisomerase DNA cleavage sites with SHAN-seq
Ian L. Morgan, Shannon J. McKie, Rachel Kim, Yeonee Seol, Jing Xu, Gabor Harami, Anthony Maxwell, Keir C. Neuman
This study develops SHAN-seq to map type II topoisomerase cleavage sites on DNA with high sensitivity, revealing hundreds of sites and enzyme-specific variations.
bioRxiv · May 17, 2024 · PreprintBiochemistry