Jing Xu

Glutamine-regulated VCP acetylation creates a proteostasis vulnerability in RB1-deficient tumor

This study identifies VCP inhibition as a therapeutic strategy for RB1-deficient tumors by revealing glutamine-regulated VCP acetylation as a proteostasis vulnerability.

TetraFuse: A Synergistic Four-Dimensional Dynamic Fusion Framework for Efficient and Robust Medical Image Classification

TetraFuse improves medical image classification by integrating four domains to balance accuracy and efficiency, achieving high performance with reduced computational demand.

Modulation of Intrauterine Adhesion Fibrosis by Lactobacillus delbrueckii: Insights from ERK1/2 Pathway Inhibition and Multi-omics Analyses

This study shows that Lactobacillus delbrueckii reduces intrauterine adhesion fibrosis by inhibiting ERK1/2 signaling and increasing 3-HAA levels, based on clinical, microbiome, transcriptomic, and metabolomic analyses.

Phage CRISPR-like regulatory RNAs silence multilayered bacterial immune systems

The paper identifies viral crlRNAs that suppress bacterial immunity by reprogramming Cas proteins and demonstrates their potential for mammalian genome editing.

A Self-Assembling Immune-Featured Osteosarcoma Patient/PDX Derived Organoid Model and Biobank for Personalized Immune Therapy

The paper develops a patient/PDX-derived osteosarcoma organoid model and biobank to enable rapid testing of personalized immune therapies and drug development.

Highly sensitive mapping of in vitro type II topoisomerase DNA cleavage sites with SHAN-seq

This study develops SHAN-seq to map type II topoisomerase cleavage sites on DNA with high sensitivity, revealing hundreds of sites and enzyme-specific variations.

Distribution of duck-origin parvovirus in Cherry Valley ducks in vivo over time and histopathological investigation

This study quantifies and localizes duck-origin parvovirus in Cherry Valley ducks using qPCR and IHC, identifying key target tissues and viral dissemination pathways.