Lipid droplet accumulation drives glutamine-dependent NLRP3 inflammasome activation
Najd M. Aljadeed, Erato Pambori, Yujia Zhang, Gregory O. Austin, Antoni Olona, Guido Franzoso, Shamith Samarajiwa, Alejandra Tomás, Frederick W.K. Tam, Paras Anand
This study shows that lipid droplet accumulation promotes NLRP3 inflammasome activation through glutamine-dependent metabolic reprogramming in macrophages.
bioRxiv · Jan 14, 2026 · PreprintImmunology