Author

Gregory O. Austin

Imperial College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alejandra TomásiD· 2 shared Affiong I OquaiD· 1 shared Alex MontoyaiD· 1 shared Antoni Olona· 1 shared Ben JonesiD· 1 shared Christopher Arthur ReynoldsiD· 1 shared Denise L. WootteniD· 1 shared Dominic J. WithersiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Alejandra TomásORCID

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2 papers

Recent·Most cited

In vivo functional profiling and structural characterisation of the human Glp1r A316T variant

Liliane El Eid, Yusman Manchanda, Gregory O. Austin, Kieran Deane-Alder, Roxana‐Maria Rujan, Zamara Mariam, Affiong I Oqua, Matthew J. Belousoff, Jorge Bernardino de la Serna, Kyle W. Sloop, Guy A. Rutter, Alex Montoya, Dominic J. Withers, Steven J. Millership, Karim Bouzakri, , Alejandra Tomás

This study investigates the human Glp1r A316T variant's effects on glucose metabolism and GLP-1RA responses using mouse models and structural analyses.

Science Advances · Feb 4, 2026Peer-reviewedCell Biology

Lipid droplet accumulation drives glutamine-dependent NLRP3 inflammasome activation

Najd M. Aljadeed, Erato Pambori, Yujia Zhang, Gregory O. Austin, Antoni Olona, Guido Franzoso, Shamith Samarajiwa, Alejandra Tomás, Frederick W.K. Tam, Paras Anand

This study shows that lipid droplet accumulation promotes NLRP3 inflammasome activation through glutamine-dependent metabolic reprogramming in macrophages.

bioRxiv · Jan 14, 2026 · PreprintImmunology